PUBLIC ATTITUDES IN JAPAN TOWARD THE REPRODUCTIVE USE OF GAMETES DERIVED FROM HUMAN-INDUCED PLURIPOTENT STEM CELLS

Public attitudes in Japan toward the reproductive use of gametes derived from human-induced pluripotent stem cells

Purpose: To investigate the interests of the Japanese general public in the reproductive use of in vitro derived (IVD)-gametes.Methods: We conducted an online survey and obtained answers from 3096 respondents.Results: More than half of the respondents agreed ACCESSORIES with the reproductive use of IVD-gametes by infertile heterosexual married coup

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Effects of chronic sleep deprivation on the extracellular signal-regulated kinase pathway in the temporomandibular joint of rats.

OBJECTIVES: To examine the possible involvement and regulatory mechanisms of extracellular signal-regulated kinase (ERK) pathway in the temporomandibular joint (TMJ) of rats subjected to chronic sleep deprivation (CSD).METHODS: Rats were subjected to CSD using the modified multiple platform method (MMPM).The serum levels of corticosterone (CORT) an

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Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study

Mengjing Wang,1,2,* Xuehui Sun,3,* Li Ni,1 Minmin Zhang,1 Jiaying Zhang,4 Guoxin Ye,1 Li Jin,2,3 Xiaofeng Wang,2,3 Jing Chen1,2 1Nephrology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic

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Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer.

Downregulation of the tight junction protein claudin 1 is a frequent event in breast cancer and is associated with recurrence, metastasis, and reduced survival, suggesting a tumor suppressor role for this protein.Tumor suppressor genes are often epigenetically silenced in cancer.Downregulation of claudin 1 via DNA promoter methylation may thus be a

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